STEM CELLS
BIOLOGY LAB
José Bragança
Our group is interested in genes and regulatory pathways that control pluripotent stem cells (ESC - Embryonic Stem Cells/iPSC - induced pluripotent Stem cells) self-renewal and differentiation. The long-term aim of our work is to understand the molecular mechanisms involved in pluripotency and differentiation processes occurring in mouse and human cells in order to achieve cell-types specification in vitro for therapeutic purposes, and understand mechanisms of diseases.
GROUP MEMBERS
PUBLICATIONS
RECENT PUBLICATIONS
Bragança J, Pinto R, Silva B, Marques N, Leitão HS, Fernandes MT – Charting the path: navigating embryonic development to potentially safeguard against congenital heart defects – J. Pers. Med. (2023), 13, 1263.
Esteves F, Brito D, Rajado AT, Silva N, Apolónio J, Roberto VP, Araújo IM, Nóbrega C, Castelo-Branco P, Bragança J and ALFAScore Consortium – Reprogramming iPSCs to study age-related diseases: models, therapeutics, and clinical trials – Mech. Ageing Dev. (2023) 214, 111854.
Correia CD, Ferreira A, Fernandes MT, Silva BM, Esteves F, Leitão HL, Bragança J and Calado SM - Human Stem Cells for cardiac disease modeling and (pre)clinical applications – are we on the road to success? – Cells (2023), 12, 1727.