STEM CELLS
BIOLOGY LAB
José Bragança
Our group is interested in genes and regulatory pathways that control pluripotent stem cells (ESC - Embryonic Stem Cells/iPSC - induced pluripotent Stem cells) self-renewal and differentiation. The long-term aim of our work is to understand the molecular mechanisms involved in pluripotency and differentiation processes occurring in mouse and human cells in order to achieve cell-types specification in vitro for therapeutic purposes, and understand mechanisms of diseases.
GROUP MEMBERS
PUBLICATIONS
RECENT PUBLICATIONS
García-Ortega MB, Aparicio E, Griñán-Lisón C, Jiménez G, López-Ruiz E, Palacios JL, Ruiz-Alcalá G, Alba C, Martínez A, Boulaiz H, Perán M, Hackenberg M, Bragança J, Calado SM, Marchal JA and García Chaves MA – “Interferon-alpha decreases cancer stem cell properties and modulates exosomes in Malignant Melanoma” – Cancers (2023), 15, 3666.
Correia CD, Ferreira A, Fernandes MT, Silva BM, Esteves F, Leitão HL, Bragança J and Calado SM - Human Stem Cells for cardiac disease modeling and (pre)clinical applications – are we on the road to success? – Cells (2023), 12, 1727.
Silva N, Rajado AT, Esteves F, Brito D, Apolónio J, Roberto VP, Binnie A, ALFAScore Consortium, Araújo IM, Nóbrega C, Bragança J and Castelo-Branco P – Measuring healthy ageing – Current and future tools – Biogerontology (2023), https://doi.org/10.1007/s10522-023-10041-2