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Our group is interested in genes and regulatory pathways that control pluripotent stem cells (ESC - Embryonic Stem Cells/iPSC - induced pluripotent Stem cells) self-renewal and differentiation. The long-term aim of our work is to understand the molecular mechanisms involved in pluripotency and differentiation processes occurring in mouse and human cells in order to achieve cell-types specification in vitro for therapeutic purposes, and understand mechanisms of diseases.


Helena Santos Leitão (MD, PhD),

trained radiologist expert in thoracic and abdominopelvic imaging, has joined our research group at the Algarve  Biomedical Centre Research Institute (ABC-RI), University of Algarve.





Heidari MM, Manshadi SAM, Eshghi AR, Talebi F, Khatami M, Bragança J, Ordooei M, Chamani R and Ghasemi F – “Mutational and bioinformatics analysis of the NKX2.1 gene in a cohort of Iranian pediatric patients with congenital hypothyroidism (CH)” - Physiology International – published online 7 June 2022


Malho Guedes A, Calças Marques R, Ribeiro B, Fernandes MT, Faísca M, Silva AP, Bragança J, Rodrigues A – “Peritoneal protein loss, inflammation and nutrition: refuting myths”, Front. Med. (2022) 9, Article 884061.


Bragança J, Figueiredo S, Rego CA, dos Reis Conceição F, Neves de Jesus S “UALGORITMO, a new instrument of the University of Algarve for scientific outreach” – BioChem (2022) 2, 93-103.